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LY-411575: Potent γ-Secretase Inhibitor for Alzheimer’s a...
2025-10-23
LY-411575 delivers unmatched precision in modulating amyloid beta production and Notch pathway signaling, making it a gold-standard tool for Alzheimer’s and oncology research. Its ultra-low IC50, robust solubility, and proven in vivo efficacy empower advanced experimental designs where reliability and mechanistic clarity are essential.
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LY-411575: Potent Gamma-Secretase Inhibitor for Precision...
2025-10-22
LY-411575 stands out as a potent γ-secretase inhibitor with an ultra-low IC50, enabling researchers to disentangle amyloid beta production and Notch signaling with unmatched specificity. Its dual utility in Alzheimer's disease and cancer models makes it indispensable for advanced translational workflows and next-generation combination strategies.
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Necrostatin 2: Precision RIPK2 Kinase Inhibition in Necro...
2025-10-21
Necrostatin 2 (Nec-2) is revolutionizing necroptosis research with its nanomolar potency and high specificity for RIPK2. Unlock advanced experimental workflows and troubleshoot complex cell death models using this small molecule necroptosis inhibitor, especially in apoptosis-resistant and ischemic stroke settings.
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Erastin: Unraveling Ferroptosis in Tumor Cells with KRAS/...
2025-10-20
Explore how Erastin acts as a precision ferroptosis inducer in tumor cells with KRAS or BRAF mutations. This article uniquely bridges mechanistic insights with the latest cell death research and highlights translational opportunities in cancer therapy targeting ferroptosis.
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AP20187: Mechanistic Precision and Strategic Leverage in ...
2025-10-19
This thought-leadership article synthesizes recent mechanistic discoveries and translational strategies for leveraging AP20187—a synthetic cell-permeable dimerizer—in regulated cell therapy, gene expression control, and metabolic regulation. Drawing on cutting-edge findings in 14-3-3 protein signaling, autophagy, and oncology, it provides actionable guidance for translational researchers seeking to harness next-generation chemical inducers of dimerization for programmable therapeutics. The content uniquely escalates beyond product pages, offering a visionary, evidence-based perspective contextualized within the frontiers of synthetic biology and translational medicine.
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Z-YVAD-FMK: Redefining Caspase-1 Inhibition for Translati...
2025-10-18
This thought-leadership article explores the transformative impact of Z-YVAD-FMK, a potent irreversible caspase-1 inhibitor, on translational research. Bridging mechanistic insight with strategic guidance, it highlights new findings on caspase-1’s role in pyroptosis and tumorigenesis, outlines best practices for experimental design, compares Z-YVAD-FMK to competing tools, and charts a visionary path for leveraging precise inflammasome modulation in disease modeling and therapeutic discovery.
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3-Methyladenine: Advanced Insights on PI3K Inhibition and...
2025-10-17
Explore the multifaceted role of 3-Methyladenine as a class III PI3K inhibitor and autophagy inhibitor in dissecting cancer cell survival, migration, and ferroptosis escape. This article delves deeper into the mechanistic interplay and translational opportunities for cancer research.
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PPT: A Selective ERα Agonist Transforming Hormone Recepto...
2025-10-16
PPT (Propyl Pyrazole Triol) empowers researchers with unmatched selectivity for estrogen receptor alpha, enabling precise dissection of ERα-mediated signaling in cancer and reproductive biology. Its robust performance in gene expression and in vivo models distinguishes it as an indispensable tool for hormone receptor research and advanced functional genomics.
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ACK can be localized to clathrin
2023-07-06
ACK1 can be localized to clathrin-coated vesicles [1]. The association of SNX9 with synaptojanin-1 would suggest the two cooperate during endocytosis at the synapse by coupling the sorting nexin to changes in phospholipid composition. ACK1 in turn negatively regulates the association of SNX9 with ta
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As a continuation of our
2023-07-06
As a continuation of our search for a selective AChE radioligand bearing a meta-F substituted N-benzyl moiety, we designed and synthesized a novel meta-F-CP-118,954 analog along with a meta-18F-labeled form via diaryliodonium salt-based precursor (Fig. 1). For comparative purposes, we incorporate th
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Overexpression of SMAD and SMAD
2023-07-06
Overexpression of SMAD3 and SMAD4 strongly enhanced luciferase activity of the new pN10 reporter gene construct which was further reinforced by addition of TGFβ. Serial mutations of SBE-1 and SBE-2 led to a slight loss in 5-LO promoter inducibility. The data demonstrate that the two SBEs within the
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In this study we have isolated genes that encode
2023-07-05
In this study, we have isolated (E)-2-Decenoic acid that encode ACL from G. zeae through random mutagenesis by restriction enzyme-mediated integration (REMI). The mutant Z39P186 where the ACL gene had been disrupted showed defects in vegetative growth, asexual and sexual development, virulence, and
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In considering the roles of these enzymes in
2023-07-05
In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty Efaproxiral Sodium synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a
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Hypoxia of the adipose tissue is a
2023-07-05
Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an
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Beside estrogen several classes of compounds
2023-07-05
Beside estrogen, several pka kinase of compounds have shown significant neuroprotective efficacy when administered shortly after the induction of animal models of stroke, including glutamate (NMDA) receptor antagonists and zinc chelators [25], [26], [27]. Effects of these or other neuroprotective a