• For human health risk assessment of chemicals a

  2020-03-05

  

  For human health risk assessment of chemicals, a default uncertainty factor (UF) of 3.16 is used to capture inter individual variation in toxicokinetics (Dorne and Renwick, 2005). However, the scientific background for this default UF remains unsatisfactory., Several studies have reported that a fac

• This work aimed to investigate whether the increase

  2020-03-05

  

  This work aimed to investigate whether the increase in liver lipid depots, observed in the fetuses from rats fed a saturated-fat-rich diet, persists later in life in the offspring (a) at 21days of age immediately after weaning and (b) at 140days of age, after healthy nourishing. Furthermore, we want

• br Introduction Breast cancer is

  2020-03-05

  

  Introduction Breast cancer is the most common cancer in women and one of the leading causes of death worldwide. Estrogen receptor alpha (ERα, “wild-type” estrogen receptor), encoded by the estrogen receptor1 (ESR1) gene, is expressed in approximately 70% of all breast cancers. Hormonal therapy ha

• br Acknowledgments This work was supported by R

  2020-03-05

  

  Acknowledgments This work was supported by Région Auvergne “Nouveau chercheur”. This study has been performed with the assistance of Christelle Damon-Soubeyrand for histology technical assistance using “Anipath” Platform (GReD) and Sandrine Plantade, Keredine Ouchen and Philippe Mazuel for animal

• However in many of the

  2020-03-05

  

  However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD 2189 tissue, the concentration was 150mM [30], while that for the extraction of the

• Significantly elevated levels of DNA damage observed in peri

  2020-03-04

  

  Significantly elevated levels of DNA damage observed in peripheral blood of tea garden women workers indicate the occupational exposure. The same was observed in cholinesterase activities, which detected lower activity in the exposed group compared to non-exposed. Large volumes of pesticides are use

• To further verify the effect of BBR on ACAT

  2020-03-04

  

  To further verify the effect of BBR on ACAT2 protein expression, we have conducted an in vitro permeability assay using Caco-2 monolayer. This assay has long been used to predict the in vivo Pasireotide and bioavailability of a compound. It was observed that the amount of cholesterol esters in the

• br Results br Discussion CCA is

  2020-03-04

  

  Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m

• In addition to playing important roles in

  2020-03-04

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the Shikonin receptor of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a)

• br Results br Discussion Many studies have

  2020-03-04

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific STK393606 type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous studi

• br Regulation of p via

  2020-03-04

  

  Regulation of p53 via the ubiquitin-proteasome pathway Studies into regulation of p53 via PTM processes that involve phosphorylation, acetylation, ubiquitination, SUMOylation, neddylation, and methylation are being increasingly reported [23], [24]. Phosphorylation and acetylation of p53 stimulate

• We then evaluated in vivo DHODH mRNA expression

  2020-03-04

  

  We then evaluated in vivo DHODH mRNA Bax channel blocker using data from TCGA (Lee, Palm, Grimes, & Ji, 2015). To perform a pan-disease comparison of DHODH expression, log2 TPM expression values were converted to z-scores calculated per patient. Fig. 6 shows that across all 34 diseases (9726 unique

• br How does DDR receptor activated to induce Osteoarthritis

  2020-03-04

  

  How does DDR2 receptor activated to induce Osteoarthritis Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides bcl-xl inhibitor for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocyt

• br P Y receptor structure br Pharmacology Several

  2020-03-04

  

  P2Y receptor structure Pharmacology Several subtype selective compounds have been developed in recent years (Jacobson and Müller, 2016; Rafehi and Müller, 2018). These compounds are helpful tools for analyzing the roles of P2Y receptor subtypes in physiology and pathophysiology. The present ar

• Previous studies revealed the expression of

  2020-03-04

  

  Previous studies revealed the expression of the CCR3 receptor in neurons and its neuroprotective function using mice lacking CCR3 expression (Wainwright et al., 2009). The regulation of CCR3 receptor expression in the microglia and astrocytes was shown in neurological disorders and has been demonstr

14562 records 803/971 page Previous Next First page 上5页 801802803804805 下5页 Last page