• Dehydrogenation by a KSTD is also a crucial step

  2020-07-30

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during CI 976 degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroid degradatio

• There are few studies targeting

  2020-07-30

  

  There are few studies targeting cocaine and corticotropin-releasing factor CRF2 receptor. Boyson and co-workers (Boyson et al., 2014) found that administration of Astressin2-B directly into the ventral tegmental area 20 min before social defeat reversed the escalation and sensitization to dopamine r

• The biocontrol agent BCA Bacillus amyloliquefaciens CPA form

  2020-07-30

  

  The biocontrol agent (BCA) Bacillus amyloliquefaciens CPA-8, formerly known as Bacillus subtilis (Gotor-Vila et al., 2016) has been reported as an effective antagonist against brown rot caused by Monilinia spp. (Casals et al., 2012; Gotor-Vila et al., 2017a; Yánez-Mendizábal et al., 2011), the wound

• br Introduction Safety critical systems are defined

  2020-07-30

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated withi

• br Introduction Pattern separation is the ability to make

  2020-07-29

  

  Introduction Pattern separation is the ability to make distinct representations from highly overlapping information, a process which is important for memory encoding (Clelland et al., 2009). For correct pattern separation, old information needs to be retrieved and compared to new information. If

• selonsertib br Materials and methods br Results br Discussio

  2020-07-29

  

  Materials and methods Results Discussion The aim of the studies described in this paper was to identify determinants of the sensitivity of human colorectal cancer and NSCLC cell lines to the ZD2767 ADEPT system. In particular, the role of DNA–DNA interstrand cross-linking and TP53 status we

• Interestingly increased level of both

  2020-07-29

  

  Interestingly, increased level of both circulating ET-1 and urinary excretion of ET-1 have been observed in patients treated with nephrotoxic immunosuppressive agents as cyclosporine A and tacrolimus (Slowinski et al., 2002). Other nephrotoxic agents, such as cisplatin, also increase urinary excreti

• Recently Hopkins et al reported a longer form

  2020-07-28

  

  Recently, Hopkins et al. reported a longer form of PTEN (PTEN-Long) that is secreted into adjacent Amsacrine mg and antagonizes PI3K/AKT signaling (Hopkins et al., 2013). This study significantly expands the functional scope of the PTEN family from intracellular to extracellular. Although PTEN-Long

• br Discussion Type I collagen

  2020-07-28

  

  Discussion Type I collagen is an important adhesive protein for use as scaffolding material for various tissue engineering applications [4], [5]. An understanding of how the various features of collagen matrices influence cell behavior is hence of great current interest [6]. Even for monotypic li

• Despite the differences in the clustering abilities of DDR b

  2020-07-28

  

  Despite the differences in the clustering abilities of DDR1b versus DDR2 upon ligand administration, we also noted striking similarities in the spatial distribution and phosphorylation of DDR1b-YFP and DDR2-GFP. We show for the first time that in MC3T3-E1 cells, after 4 h of collagen administration,

• The role of DDR in glomerular injury has been then

  2020-07-28

  

  The role of DDR1 in glomerular injury has been then further studied by the Chatziantoniou group in experimentally-induced crescentic glomerulonephritis, by injection of alloimmune sheep nephrotoxic serum (NTS) [54]. Glomerulonephritis produced a 17-fold increase of DDR1 expression, predominantly in

• Changes in DAPK concentration or catalytic activity

  2020-07-28

  

  Changes in DAPK concentration or catalytic activity in response to cerebral ischemia have not been reported. This knowledge is required for a complete understanding of the role of DAPK in ischemia, and for future investigations into the potential of DAPK as a therapeutic target for the treatment of

• RO-3 According to several authors MM is consistently precede

  2020-07-28

  

  According to several authors, MM is consistently preceded by a monoclonal gammopathy of uncertain significance (MGUS)—an asymptomatic (no CRAB criteria) premalignant entity that has been reported to have a transformation rate to MM of approximately 1% per year. Smoldering multiple myeloma (SMM) is a

• A range of therapies exists for the

  2020-07-28

  

  A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al., 2008). Despite of these notable successes, there are still major unmet medical needs in the t

• br Materials and methods br Results

  2020-07-28

  

  Materials and methods Results Discussion Acknowledgements We thank P.J. Focia and Z. Wawrzak for support in data collection and S. Gomes for support in generating IL-34 mutant clones. X.H. is supported by the NIH grant 1R01GM078055. The Structural Biology Facility is supported by the R.H

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