• br AR signaling and urothelial cancer progression As shown

  2024-06-17

  

  AR signaling and urothelial cancer progression As shown in other types of malignancies, such as prostate cancer cells, it has been documented that androgens induce AR expression and its nuclear translocation as well as ARE promoter activity in urothelial cancer cells (Chen et al., 2003, Izumi et 

• K02288 Tephrosia purpurea Linn pers Fabaceae a widely growin

  2024-06-14

  

  Tephrosia purpurea (Linn.) pers, (Fabaceae), a widely growing herbaceous perennial is reported to exhibit significant anti-hyperglycemic activity in animal models [7], [8], [9] as well as able to delay the development of diabetic complications [10], [11]. Recently, we have reported T. purpurea for i

• In our previous study we showed that

  2024-06-14

  

  In our previous study we showed that normal and cancerous Topiroxostat of kidney exhibit the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Furthermore, the activity of class I ADH isoenzymes and total ADH were significantly higher in cancer tissue than in unchanged renal cells. Moreo

• Heparin The AR signalling pathways play important roles in s

  2024-06-14

  

  The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour Heparin and seems implicated in pro- or anti-apoptotic effects [36]. In particular, activatio

• Pramipexole br Introduction Myasthenia gravis MG is an autoi

  2024-06-14

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against Pramipexole receptor (AChR) [1]. In AChR negative MG patients an

• Several alterations have been or can be

  2024-06-14

  

  Several alterations have been or can be associated to the decreased tolerance of steatotic liver to I/R injury. Previous studies demonstrated that upregulation of the mitochondrial uncoupling protein-2 (UP2) is strictly related to the increase of I/R injury in steatotic liver [4]. UPR induction is c

• ASK belongs to the family of MAPKKK ASK mediated

  2024-06-14

  

  ASK1 belongs to the family of MAPKKK. ASK1-mediated apoptosis is involved in the pathogenesis of several diseases such as I/R injury, infectious diseases and neurodegenerative disorders [33], [34], [35]. ASK1 can be activated through different mechanisms. One mechanism is that oxidative stress direc

• Serum concentrations of acute phase proteins APP and of anti

  2024-06-13

  

  Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi

• Plant defensins are cysteine rich cationic peptides of

  2024-06-13

  

  Plant defensins are cysteine-rich cationic peptides of 5–8 kDa whose mature domain comprises 45 to 54 amino igf 1 antagonist residues, with an isoelectric point around 9. The global fold of plant defensins consists of a cysteine-stabilized motif (CSα/β) made up of an α-helix and a triple-stranded β

• br Telmisartan Telmisartan is one of the widely

  2024-06-13

  

  Telmisartan Telmisartan is one of the widely used antihypertensive agents, which has demonstrated favorable safety and tolerability profiles, both alone and in combination therapies. It has a number of pharmacological properties that distinguish it from other ARBs—the longest plasma half-life, hi

• Prostate cell growth and prostate carcinogenesis are

  2024-06-13

  

  Prostate cell growth and prostate carcinogenesis are not only mediated by androgens, they are also dependent on functional insulin receptor (IR) and insulin-like growth factor-1 (IGF-1) receptor (IGF1R) signaling. Previous studies addressed this issue and reported a correlation between high insulin

• Analysis of the enzyme activity expressed

  2024-06-13

  

  Analysis of the enzyme activity, expressed as rate of product formation per unit serum volume (20μl), between the diagnostic groups revealed that ApB activity was significantly decreased in the patient group both at recruitment and after 13months when the substrate concentration used was 1.5mM (pAP1

• It remains to elucidate whether proteolytic activity

  2024-06-13

  

  It remains to elucidate whether proteolytic activity is the cause or the consequence of changing levels of peptidergic substrates. In fact, in some cases, the expression of the enzyme does not necessarily parallel with its activity [26], [55], [57] and other factors such as a definite biochemical en

• br Experimental section br Introduction Microglia were disco

  2024-06-13

  

  Experimental section Introduction Microglia were discovered as a novel cell population in Procainamide HCl in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform lay

• br Mechanisms of specific immunotherapy Several mechanisms m

  2024-06-13

  

  Mechanisms of specific immunotherapy Several mechanisms may be involved in specific immunotherapy of EAMG by active immunization with the therapeutic vaccine in IFA. During the therapy, the therapeutic benefits result from diversion of autoantibody specificities away from pathogenic extracellular

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