• More than thirty enzymes with PLA activity have been describ

  2021-02-15

  

  More than thirty enzymes with PLA2 activity have been described and, based on sequence similarities, they are currently classified in 16 groups, each containing several sub-groups [16]. However, based on biochemical features these enzymes are frequently grouped into six major families: secreted phos

• br Molecular characterization of LEI L DNase II LEI

  2021-02-12

  

  Molecular characterization of LEI/L-DNase II LEI, like most serpins, is a metastable protein and its anti-protease activity is related to its “stressed to relaxed transition”. So that, the inhibition of elastase by the well described suicide mechanism generates the cleaved form of LEI (see Padron

• OHC is a potent regulator of LXR mediated

  2021-02-12

  

  25-OHC is a potent regulator of LXR-mediated pathways, that impact on MCC950 sodium lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]. 25-OHC is able to

• In general the DNMT encompass three different structural reg

  2021-02-12

  

  In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated

• Natural and synthetic glucocorticoids perform their biologic

  2021-02-11

  

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.

• Our previous studies have shown that in a

  2021-02-11

  

  Our previous studies have shown that in a preimplantation mouse embryo the proportion of inner to outer cells (i.e. precursors of ICM and TE, respectively) is regulated by a different frequency of differentiative cell divisions at the 8- and 16-cell stages. Low number of inner blastomeres generated

• The eNOS bp VNTR polymorphism has been found to be

  2021-02-10

  

  The eNOS 27-bp VNTR polymorphism has been found to be associated with altered plasma NO levels. This polymorphism also has been associated with many vascular diseases including hypertension, diabetic retinopathy, and diabetic nephropathy in various populations. Notably, our results were different fr

• br Funding br Disclosure of

  2021-02-10

  

  Funding Disclosure of interest Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic disease characterized by extensive deposits of the extracellular matrix (ECM) that can impair the architecture and function of the lungs (Cavazza et al., 2010). Imbalance between the prolifer

• br Results br Discussion Mucosal barriers

  2021-02-10

  

  Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune Pleuromutilin (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in ly

• br Results br Discussion Oxysterols and EBI have received gr

  2021-02-10

  

  Results Discussion Oxysterols and EBI2 have received growing attention in the field of immunology, with works highlighting an important role for EBI2 in immune cell migration. However, these studies are mainly limited to animal models (Chalmin et al., 2015, Hannedouche et al., 2011, Kelly et a

• The DNA damage response DDR is a cellular mechanism

  2021-02-10

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as signaling regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recogni

• The Nile tilapia Oreochromis niloticus

  2021-02-10

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• Such concerns do not apply to

  2021-02-10

  

  Such concerns do not apply to the anti-inflammatory actions shown by the agent, given that CR3465 proved effective in various models of inflammation including guinea pig, rat, and human. Airway inflammation, involving a complex network of local mediators, cytokines, and effector L-685,458 mg (Bradl

• Introduction Cyclin dependent kinases CDKs are a

  2021-02-10

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as JW 55 synthesis and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cycl

• From the general synthetic route

  2021-02-10

  

  From the general synthetic route, we first synthesized a directed set of analogues of general formula , keeping the synthesis simple by using a symmetrical pyrazole (R=R=Me). The SAR of a set of 30 compounds in the GTPγS binding assay turned out to be quite tight: only 4 (13%) compounds showed moder

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