• We propose that unlike other

  2020-08-10

  

  We propose that, unlike other autophagy genes, the specific increase in the expression of IRGM by pEIF2A plays a major role as a checkpoint allowing host cell survival by autophagy or host cell elimination by necroptosis. The localization of IRGM to the mitochondrial inner membrane, its ability to i

• Exposure to ultraviolet radiation with

  2020-08-10

  

  Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr

• br Ubiquitin Capture by the

  2020-08-10

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the Nilotinib correlates with processivity of

• The human serotonin hydroxytryptamine HT receptor

  2020-08-09

  

  The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per

• One series of EP receptor antagonists we

  2020-08-08

  

  One series of EP receptor antagonists we have reported is exemplified by the pyrazole derivative . We have also disclosed some related work from this series where we identified replacement heterocycles for the pyrazole, such as the thiazole derivatives and and the pyridine derivatives and . We fo

• (-)-p-Bromotetramisole Oxalate Our previous studies have dem

  2020-08-08

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• TRIM was first identified as glycogenin interacting

  2020-08-08

  

  TRIM7 was first identified as glycogenin interacting protein (GNIP) and has been reportedly involved in glycogen synthesis. Knockdown of Trim7 in the primary(KP) lung tumor vx 20 could reduce cell proliferation and decrease the tumor growth in xenograft experiments. Consistently, deletion of Trim7

• To assess whether the described cooperation between the EGFR

  2020-08-07

  

  To assess whether the described cooperation between the EGFR and FGFR receptors was relevant at the clinical level, we determined the effect on progression-free survival of FGFR1 expression in patients with adenocarcinoma who were receiving erlotinib or gefitinib. As we had observed EGFR-FGFR1 coope

• DNA ligase IV contains a conserved ligase domain

  2020-08-07

  

  DNA ligase IV contains a conserved ligase domain at its N-terminus and a tandem BRCT domain at its C-terminus (Fig. 1a) [7]. Interaction with Xrcc4 requires the region between the BRCT domains and likely part of the BRCT domain [8], [9]. The DNA ligase IV/Xrcc4 complex is large and its crystal struc

• br Drug Target Potential TM receptors

  2020-08-06

  

  Drug-Target Potential 7TM receptors and in particular class A receptors to which the 7TM receptors mentioned in this review belong, are highly druggable molecules. Approximately, 35% of all currently marketed drugs target class A 7TM receptors. There is no specific antiviral treatment for EBV. Cu

• br Wound healing is an

  2020-08-06

  

  Wound healing is an evolutionarily conserved pathophysiological paradigm of fibrogenesis. The wound healing response to injury is known to trigger functional (i.e., proliferative) and phenotypic changes throughout the skin, with involvement of multiple cell types (e.g., fibroblasts, lymphocytes, e

• br Materials and methods br Results br Discussion Herein we

  2020-08-06

  

  Materials and methods Results Discussion Herein we report the expression of shrimp Cdk-2 in hepatopancreas, gills and muscle, finding higher expression in hepatopancreas and gills and lower expression in muscle. No significant changes due to hypoxia and hypoxia reoxygenation were detected o

• TTP 22 Previous reports have demonstrated that the activatio

  2020-08-06

  

  Previous reports have demonstrated that the activation of noradrenergic terminals innervating PVN modulate the HPA axis activity in response to morphine withdrawal. Thus, naloxone-precipitated morphine withdrawal increased NA turnover and c-Fos expression in PVN concomitantly with an increase in the

• Paraffin embedded tissue blocks were transferred

  2020-08-06

  

  Paraffin embedded tissue blocks were transferred from the University of Florence, Florence, Italy, to the Department of Cellular Pathology at the Royal Free Hospital, London, UK, where the study was performed. Each tissue block was processed according to the reported CPA method and analysed for coll

• br We will work in the

  2020-08-06

  

  We will work in the notation of [3], [5], where the Cox ring of a rational T-variety of complexity one is encoded by a pair of defining matrices. Let us briefly recall the precise definitions we need from [5]; note that the setting will be slightly more flexible than the informal one given in the

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