• It is reported that sympathetic nerve activity

  2021-03-24

  

  It is reported that sympathetic nerve activity is increased in the SHR strain compared with that in the WKY strain (Judy and Farrell, 1979, Lundin et al., 1984, Sugimura et al., 2008) and NA content is increased in the CB of the New Zealand strain of hypertensive rat compared with that in normotensi

• Materials and methods Between January and December patients

  2021-03-24

  

  Materials and methods Between January 2006 and December 2008, 34 patients with GBM were treated with postoperative three-dimensional (3D) radiotherapy at Tartu University Hospital or North Estonian Medical Centre. Characteristics of patients are listed in Table 1. Results Discussion Radiothe

• br Acknowledgements This work was supported by

  2021-03-24

  

  Acknowledgements This work was supported by a Grant for the Program for the Strategic Research Foundation at Private Universities S1101017 organized by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan and JSPS KAKENHI Grant Numbers JP22560209 and JP5K05842. The

• br Discussion Electroporation is a convenient and efficient

  2021-03-24

  

  Discussion Electroporation is a convenient and efficient way to introduce foreign material into enzyme substrate [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant to successful

• A range of therapies exists for the treatment of

  2021-03-24

  

  A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al., 2008). Despite of these notable successes, there are still major unmet medical needs in the t

• Flexible alignment of isopropylphenylaminobenzimidazole with

  2021-03-24

  

  Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead 4sc 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well as the other key functional

• Park et al expanded their own model as hydrogen bonding

  2021-03-24

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino Oxytocin solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausnitz [37] for m

• br Materials and methods br Data and

  2021-03-23

  

  Materials and methods Data and statistical analysis The results were expressed as mean ± SEM. One-way analysis of variance (ANOVA), followed by Bonferroni's post-test or unpaired Student's t-test were used to determine significant differences between groups. The program used for statistical an

• Dose response analysis Fig can be performed on cells

  2021-03-23

  

  Dose response analysis (Fig. 2) can be performed on Adriamycin HCl in culture, in tissue, in animals or even in patients. Many different responses can be measured, including mRNA levels, reporter gene activity, gene product (e.g. enzyme) activity or even physiological functions such as inhibition of

• The previously described endogenous patterns of IGF induced

  2021-03-23

  

  The previously described endogenous patterns of IGF-1-induced kinase signaling, and resulting interaction between MAPK and PI3K, differ across neuronal sub-types. In R28 retinal neuron-like cells, IGF-1 treatment elicits prolonged activation (at least 80 min) of both PI3K and MAPK (Kong et al., 2016

• Our previous studies have shown that

  2021-03-23

  

  Our previous studies have shown that in a preimplantation mouse embryo the proportion of inner to outer cells (i.e. precursors of ICM and TE, respectively) is regulated by a different frequency of differentiative cell divisions at the 8- and 16-cell stages. Low number of inner blastomeres generated

• Prednisolone To identify and characterize new possible molec

  2021-03-23

  

  To identify and characterize new possible molecular targets, the mechanisms of various kinds of TCDD toxicities that occur by abnormal regulation in the downstream of AhR signals have been studied (Yoshioka et al., 2011). Experimental evidence has revealed that prostanoids (i.e., prostaglandins and

• OxLDL down regulates eNOS and up regulates

  2021-03-23

  

  OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial FTY720 Phosphate [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNOS-mediat

• The generation of ROS in addition to eliciting

  2021-03-23

  

  The generation of ROS, in addition to eliciting oxidative stress, is an important proapoptotic signal (Ott et al., 2007). Apoptosis is clearly associated with the production of ROS, since ROS generation occurs in the mitochondrial respiratory chain and disturbs mitochondrial homeostasis, which plays

• As mentioned above EBI and its ligand show some similarities

  2021-03-23

  

  As mentioned above, EBI2 and its ligand show some similarities to the sphingosine 1-phosphate (S1P)/S1P-receptor system, which mediates T cell egress from lymph nodes. Blockade of this system yielded in the first oral drug for MS patients named fingolimod. Therefore, the hope that EBI2 deficiency w

11061 records 379/738 page Previous Next First page 上5页 376377378379380 下5页 Last page